See main article: 2011 Farmers Classic. Sam Querrey was the defending champion but decided not to participate.
In the final, Ernests Gulbis defeated Mardy Fish in a close match, 5–7, 6–4, 6–4, becoming the first unseeded player to win this tournament since Radek Štěpánek in 2007.
The first four seeds received a bye into the second round.
See main article: 2011 Farmers Classic – Singles qualifying.