The 2011 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the seventh edition of the tournament which is part of the 2011 ATP Challenger Tour. It took place in Guayaquil, Ecuador between 21 and 27 November 2011.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Diego Junqueira | 100 | 1 | |
 Brazil | João Souza | 101 | 2 | |
| Brazil | Rogério Dutra da Silva | 122 | 3 | |
 Spain | Rubén Ramírez Hidalgo | 124 | 4 | |
| Wayne Odesnik | 127 | 5 | ||
| Argentina | Máximo González | 130 | 6 | |
 Italy | Alessandro Giannessi | 136 | 7 | |
| Spain | Daniel Muñoz de la Nava | 140 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Guillermo Duran Guido PellaThe following players received entry as a lucky loser into the singles main draw:
See main article: 2011 Challenger Ciudad de Guayaquil – Singles. Matteo Viola def. Guido Pella, 6–4, 6–1
See main article: 2011 Challenger Ciudad de Guayaquil – Doubles. 
Júlio César Campozano / Roberto Quiroz def. Marcel Felder / Rodrigo Grilli, 6–4, 6–1
