See main article: 2011 Brussels Open. World No. 1 Caroline Wozniacki won the title, beating Peng Shuai in the final 2–6, 6–3, 6–3. It was Wozniacki's 16th career title and 4th of the year.
The top two seeds received a bye into the second round.
See main article: 2011 Brussels Open – Singles qualifying.