See main article: 2011 Barcelona Open Banco Sabadell. Rafael Nadal defeated David Ferrer in the final, 6–2, 6–4, to win his record-extending sixth title at the Barcelona Open.
Fernando Verdasco was the defending champion but chose not to compete this year.
The top eight seeds received a bye into the second round.
See main article: 2011 Barcelona Open Banco Sabadell – Singles qualifying.