See main article: 2011 Atlanta Tennis Championships. Mardy Fish was the defending champion, and in a repeat of the previous year's final, he successfully defended his title by defeating his compatriot John Isner after dropping the opening set. This time the score was 3–6, 7–6(8–6), 6–2.
The top four seeds received a bye into the second round.
See main article: 2011 Atlanta Tennis Championships – Singles Qualifying.