See main article: Eurocup Basketball 2011–12. The quarterfinals were two-legged ties determined on aggregate score. The first legs were played on March 20. The return legs were played on March 27. The group winners in each tie, listed as "Team #1", hosted the second leg.
| width=250 | Team #1 | width=100 | Agg. | width=250 | Team #2 | width=88 | 1st leg | width=88 | 2nd leg |
|---|---|---|---|---|---|---|---|---|---|
Valencia Basket  | 156–138 | 71–75 | 85–63 | ||||||
Donetsk  | 145–154 |  Lietuvos Rytas | 65–76 | 80–78 | |||||
Spartak St. Petersburg  | 154–135 | 68–64 | 86–71 | ||||||
| Lokomotiv-Kuban | 153–158 | Khimki | 72–81 | 81–77 |
All times are CET (UTC+1).
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