| Competition: | Cayman Islands Premier League |
| Season: | 2011–12 |
| Matches: | 44 |
| Total Goals: | 131 |
| League Topscorer: |  Dwayne Wright (20 goals) |
| Biggest Home Win: | Elite 10–1 Cayman A. |
| Biggest Away Win: | Tigers 1–4 Scholars I. Roma United 0–3 George Town |
| Highest Scoring: | Elite 10–1 Cayman A. |
| Prevseason: | 2010–11 |
| Nextseason: | 2012–13 |
The 2011–12 Cayman Islands Premier League season was the 33rd season of top tier Cayman Islands Premier League football competition in the Cayman Islands. It began on 18 September 2011 and ended on 28 April 2012.
Elite SC unsuccessfully defended its second successive 2011 title.
East End United were relegated to the Cayman Islands First Division after finishing eighth place in last season's competition. Taking their place in the competition were the champions of the First Division, Cayman Athletic SC.
Another spot in the league was available through a promotion/relegation playoff between the 7th-place finisher in the Premier League, Tigers FC, and the runners-up of the First Division, Academy SC. Tigers won this playoff and remained in the competition.
| Team | Home city | Home ground | |
|---|---|---|---|
| Bodden Town Stadium | |||
| The Annex | |||
| Ed Bush Stadium | |||
The 7th place team in this competition will face the runners up of the First Division for a place in next season's competition.