| Date: | July 26 – August 1 |
| Edition: | 7th |
| Location: | Cordenons, Italy |
| Champs: |  Steve Darcis |
| Champd: | Robin Haase / Rogier Wassen |
The 2010 Zucchetti Kos Tennis Cup was a professional tennis tournament played on outdoor red clay courts. It was the seventh edition of the tournament which was part of the Tretorn SERIE+ of the 2010 ATP Challenger Tour. It took place in Cordenons, Italy between 26 July and 1 August 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
 Argentina | Carlos Berlocq | 101 | 1 | |
| Rui Machado | 123 | 2 | ||
 Austria | Daniel Köllerer | 124 | 3 | |
| Austria | Martin Fischer | 128 | 4 | |
 France | Édouard Roger-Vasselin | 129 | 5 | |
 Romania | Adrian Ungur | 131 | 6 | |
 Spain | Albert Ramos-Viñolas | 140 | 7 | |
| Belgium | Steve Darcis | 142 | 8 |
The following players received wildcards into the singles main draw:
Daniel Köllerer Christophe Rochus Adrian UngurThe following players received entry from the qualifying draw:
Massimo Bosa
Andrej Martin Gianluca NasoSee main article: 2010 Zucchetti Kos Tennis Cup – Singles. Steve Darcis def. Daniel Muñoz-de la Nava, 6–2, 6–4
See main article: 2010 Zucchetti Kos Tennis Cup – Doubles. Robin Haase / Rogier Wassen def. 
James Cerretani / 
Adil Shamasdin, 7–6(14), 7–5