| Event: | Men's 100 kg |
| Championship: | 2010 World Judo Championships |
| Location: | Tokyo, Japan |
| Gold: | Takamasa Anai |
| Gold Value: | 1 |
| Goldnoc: | JPN |
| Silver: | Henk Grol |
| Silvernoc: | NED |
| Bronze: | Oreidis Despaigne |
| Bronzenoc: | CUB |
| Bronze2: | Thierry Fabre |
| Bronzenoc2: | FRA |
The Men's -100 kg competition at the 2010 World Judo Championships was held at 9 September at the Yoyogi National Gymnasium in Tokyo, Japan. 58 competitors contested for the medals, being split in 4 Pools where the winner advanced to the medal round.