See main article: article and 2010 US Open (tennis).
Defending champion Kim Clijsters defeated Vera Zvonareva in the final, 6–2, 6–1 to win the women's singles tennis title at the 2010 US Open. It was her third US Open title and third major title overall.
World No. 1 and three-time champion Serena Williams withdrew from the tournament due to a foot surgery sustained from an exhibition match. Caroline Wozniacki was in contention to gain the top ranking by winning the title, but lost to Zvonareva in the semifinals.
This was the final major appearance for former world No. 3 Elena Dementieva; she was defeated in the fourth round by Samantha Stosur.
See main article: article and 2010 US Open – Women's singles qualifying.
| Category |  Clijsters |  Zvonareva | |
|---|---|---|---|
| 1st serve % | 37/48 (77%) | 27/41 (66%) | |
| 1st serve points won | 29 of 37 = 78% | 13 of 27 = 48% | |
| 2nd serve points won | 6 of 11 = 55% | 5 of 14 = 36% | |
| Total service points won | 35 of 48 = 72.92% | 18 of 41 = 43.90% | |
| Aces | 1 | 1 | |
| Double faults | 2 | 4 | |
| Winners | 17 | 6 | |
| Unforced errors | 15 | 24 | |
| Net points won | 10 of 12 = 83% | 4 of 9 = 44% | |
| Break points converted | 4 of 5 = 80% | 0 of 2 = 0% | |
| Return points won | 23 of 41 = 56% | 13 of 48 = 27% | |
| Total points won | bgcolor=98FB989 | 58 | 31 |
| Source | |||