See main article: 2010 US Open (tennis).
Four-time defending champion Esther Vergeer and her partner Sharon Walraven defeated Daniela Di Toro and Aniek van Koot in the final, 6–3, 6–3 to win the women's doubles wheelchair tennis title at the 2010 US Open.
Korie Homan and Vergeer were the reigning champions, but Homan did not participate.