See main article: 2010 US Open (tennis). Lukáš Dlouhý and Leander Paes were the defending champions, but lost in the first round to Martin Damm and Filip Polášek 6–7(7–9), 6–3, 6–4.
Bob and Mike Bryan won in the final 7–6(7–5), 7–6(7–4), against Rohan Bopanna and Aisam-ul-Haq Qureshi.