| Date: | 13–19 September |
| Edition: | 2nd |
| Surface: | Hard |
| Location: | Tulsa, United States |
| Champs: |  Bobby Reynolds |
| Champd: | Andrew Anderson / Fritz Wolmarans |
The 2010 USTA Challenger of Oklahoma was a professional tennis tournament played on hard courts. It was the 18th edition of the tournament which is part of the 2010 ATP Challenger Tour. It took place in Tulsa, United States between 13 and 19 September 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
| Taylor Dent | 72 | 1 | ||
| Donald Young | 100 | 2 | ||
| Kevin Kim | 151 | 3 | ||
| Jesse Levine | 165 | 4 | ||
| Jesse Witten | 179 | 5 | ||
| Tim Smyczek | 186 | 6 | ||
| Lester Cook | 222 | 7 | ||
| Michael Yani | 226 | 8 |
The following players received wildcards into the singles main draw:
David Martin Phillip Simmonds Blake Strode
Mark van EldenThe following players received entry from the qualifying draw:
Ionuț Beleleu Andrei Dăescu
Oleksandr NedovyesovSee main article: article and 2010 USTA Challenger of Oklahoma – Singles. Bobby Reynolds def. Lester Cook, 6–3, 6–3
See main article: article and 2010 USTA Challenger of Oklahoma – Doubles. Andrew Anderson / Fritz Wolmarans def. Brett Joelson / 
Chris Klingemann, 6–2, 6–3