| Champ: |  Juan Ignacio Chela |
| Runner: |  Sam Querrey |
| Score: | 5–7, 6–4, 6–3 |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
See main article: 2010 U.S. Men's Clay Court Championships. Lleyton Hewitt was the defending champion, but he lost to Juan Ignacio Chela in the quarterfinals.
Chela won in the final 5–7, 6–4, 6–3 against Sam Querrey.
The top four seeds receive a bye into the second round.