| Date: | September 7 - 12 |
| Edition: | 2nd |
| Surface: | Hard |
| Location: | Saint-Rémy-de-Provence, France |
| Champs: |  Jerzy Janowicz |
| Champd: |  Gilles Müller /  Édouard Roger-Vasselin |
The 2010 Trophée des Alpilles was a professional tennis tournament played on hard courts. It was the 2nd edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Saint-Rémy-de-Provence, France between 7 and 12 September.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
| Rainer Schüttler | 91 | 1 | ||
 Russian Federation | Igor Kunitsyn | 112 | 2 | |
| France | Édouard Roger-Vasselin | 115 | 3 | |
| France | David Guez | 122 | 4 | |
| Stéphane Bohli | 129 | 5 | ||
| France | Josselin Ouanna | 137 | 6 | |
| France | Adrian Mannarino | 152 | 7 | |
 Ireland | Conor Niland | 153 | 8 |
The following players received wildcards into the singles main draw:
Pierre-Hugues Herbert Jonathan Hilaire Jérôme InzerilloThe following players received entry from the qualifying draw:
Olivier Charroin
Laurynas Grigelis Alexandre RenardThe following players received entry as a lucky loser:
See main article: 2010 Trophée des Alpilles – Singles. Jerzy Janowicz def. Édouard Roger-Vasselin, 3–6, 7–6(8), 7–6(6)
See main article: 2010 Trophée des Alpilles – Doubles. Gilles Müller / Édouard Roger-Vasselin def. Andis Juška / Deniss Pavlovs, 6–0, 2–6, [13–11]