| Year: | 2010 |
| Team: | Tennessee State Tigers |
| Sport: | football |
| Conference: | Ohio Valley Conference |
| Short Conf: | OVC |
| Record: | 3–8 |
| Conf Record: | 0–7 |
| Head Coach: | Rod Reed |
| Hc Year: | 1st |
| Off Coach: | Mike Jones |
| Oc Year: | 1st |
The 2010 Tennessee State Tigers football team represented Tennessee State University as a member of the a member of the Ohio Valley Conference (OVC) in the 2010 NCAA Division I FCS football season. The Tigers were led by first-year head coach Rod Reed and played their home games at LP Field. They finished the season 3–8 overall and 0–7 in OVC play to finish in last place.