| Champ: | Roger Federer |
| Runner: |  Novak Djokovic |
| Score: | 6–4, 3–6, 6–1 |
| Type: | singles doubles |
| Draw: | 32 (4 / 3) |
| Seeds: | 8 |
| Before Name: | Davidoff Swiss Indoors – Singles |
| After Name: | Swiss Indoors – Singles |
See main article: 2010 Swiss Indoors. Novak Djokovic was the defending champion, but lost to Roger Federer 6–4, 3–6, 6–1 in the final.[1]