The 2010 St. Petersburg Open was a tennis tournament played on indoor hard courts. It was the 16th edition of the St. Petersburg Open, and part of the ATP World Tour 250 Series of the 2010 ATP World Tour. It was held at the Petersburg Sports and Concert Complex in Saint Petersburg, Russia, from October 25 through October 31, 2010.
| Country | Player | Rank* | Seed | |
|---|---|---|---|---|
| Mikhail Youzhny | 9 | 1 | ||
| Sergiy Stakhovsky | 35 | 2 | ||
| Janko Tipsarević | 38 | 3 | ||
| Lu Yen-hsun | 39 | 4 | ||
| Viktor Troicki | 43 | 5 | ||
| Denis Istomin | 46 | 6 | ||
| Jérémy Chardy | 49 | 7 | ||
| Victor Hănescu | 51 | 8 |
* Seeds are based on the rankings of October 18, 2010.
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2010 St. Petersburg Open – Singles. 
Mikhail Kukushkin defeated 
Mikhail Youzhny, 6–3, 7–6(7–2)
See main article: 2010 St. Petersburg Open – Doubles. 
Daniele Bracciali / Potito Starace defeated 
Rohan Bopanna / 
Aisam-ul-Haq Qureshi, 7–6(8–6), 7–6(7–5)
