See main article: 2010 Sparta Prague Open. Ksenia Lykina and Maša Zec Peškirič defeated Petra Cetkovská and Eva Hrdinová in the final 6–3, 6–4 to win the women's doubles title at the inaugural Sparta Prague Open.
Riza Zalameda (semifinals)
Lu Jingjing / Mashona Washington (first round)
Elena Bovina / 
Darya Kustova (semifinals) Ksenia Lykina / Maša Zec Peškirič (champions)