The 2010 Soweto Open was a professional tennis tournament played on hard courts. It was part of the 2010 ATP Challenger Tour. It took place in Johannesburg, South Africa between 12 and 18 April 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
 Slovakia | Lukáš Lacko | 63 | 1 | |
| Slovakia | Karol Beck | 78 | 2 | |
| Lu Yen-hsun | 98 | 3 | ||
 Israel | Harel Levy | 125 | 4 | |
 Jamaica | Dustin Brown | 126 | 5 | |
| Stéphane Bohli | 140 | 6 | ||
| Grega Žemlja | 144 | 7 | ||
| Igor Sijsling | 162 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2010 Soweto Open – Singles. Dustin Brown def. Izak van der Merwe, 7–6(2), 6–3
See main article: 2010 Soweto Open – Doubles. 
Nicolas Mahut / Lovro Zovko def. Raven Klaasen / Izak van der Merwe, 6–2, 6–2
