The 2010 Mercury Insurance Open was a women's tennis tournament played on outdoor hard courts. It was the first edition of the Southern California Open since the tournament left the tour in 2007. It was classified as one of the WTA Premier tournaments of the 2010 WTA Tour. It was played in San Diego, California, United States. Svetlana Kuznetsova won the singles title.
See main article: 2010 Mercury Insurance Open – Singles. 
Svetlana Kuznetsova defeated 
Agnieszka Radwańska, 6–4, 6–7(7–9), 6–3
See main article: 2010 Mercury Insurance Open – Doubles. Maria Kirilenko / 
Zheng Jie defeated 
Lisa Raymond / 
Rennae Stubbs, 6–4, 6–4
| Player | Nationality | Ranking* | Seed | |
|---|---|---|---|---|
 Serbia | 2 | 1 | ||
| Samantha Stosur | Australia | 5 | 2 | |
| Russia | 9 | 3 | ||
| Poland | 11 | 4 | ||
 Italy | 12 | 5 | ||
| 14 | 6 | |||
 Israel | 16 | 7 | ||
| Yanina Wickmayer |  Belgium | 17 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry by a lucky loser spot:
