See main article: 2010 Sony Ericsson Open. Svetlana Kuznetsova and Amélie Mauresmo were the defending champions, but Mauresmo retired from the sport on December 3, 2009.
Kuznetsova chose to compete with Alicia Molik, but they lost in the first round to Gisela Dulko and Flavia Pennetta.
The unseeded pair Gisela Dulko and Flavia Pennetta won in the final 6–3, 4–6, [10–7], against Nadia Petrova and Samantha Stosur.
Liezel Huber (first round)
Nuria Llagostera Vives / María José Martínez Sánchez (second round)
Nadia Petrova / 
Samantha Stosur (finals) Lisa Raymond / Rennae Stubbs (semifinals) Alisa Kleybanova / 
Francesca Schiavone (quarterfinals) Bethanie Mattek-Sands / 
Yan Zi (first round) Ekaterina Makarova / Peng Shuai (quarterfinals)