The 2010 Sicilia Classic was a professional tennis tournament played on outdoor red clay courts. It was the second edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Palermo, Italy between 4 and 10 October 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Filippo Volandri | 98 | 1 | |
| Italy | Simone Bolelli | 117 | 2 | |
 Kazakhstan | Yuri Schukin | 125 | 3 | |
 Austria | Martin Fischer | 138 | 4 | |
| Italy | Alessio di Mauro | 158 | 5 | |
 Romania | Adrian Ungur | 159 | 6 | |
 France | Éric Prodon | 160 | 7 | |
 Morocco | Reda El Amrani | 164 | 8 |
The following players received wildcards into the singles main draw:
The following players received a special entrant into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2010 Sicilia Classic – Singles. 
Attila Balázs def. Martin Fischer, 7–6(4), 2–6, 6–1
See main article: 2010 Sicilia Classic – Doubles. Martin Fischer / Philipp Oswald def. Alessandro Motti / Simone Vagnozzi, 4–6, 6–2, [10–6]
