| Year: | 2010 |
| Team: | Shepherd Rams |
| Sport: | football |
| Conference: | West Virginia Intercollegiate Athletic Conference |
| Short Conf: | WVIAC |
| Afcarank: | 7[1] |
| Record: | 12–2 |
| Conf Record: | 7–1 |
| Head Coach: | Monte Cater |
| Hc Year: | 24th |
| Off Coach: | Ernie McCook |
| Oc Year: | 1st |
| Def Coach: | Josh Kline |
| Dc Year: | 2nd |
| Stadium: | Ram Stadium |
| Champion: | WVIAC champion |
| Bowl: | NCAA Division II Semifinal |
| Bowl Result: | L 17–29 at |
The 2010 Shepherd Rams football team represented Shepherd University as a member of the West Virginia Intercollegiate Athletic Conference (WVIAC) during the 2010 NCAA Division II football season. Led by 24th-year head coach Monte Cater, the Rams compiled an overall record of 12–2 with a conference mark of 7–1, winning the WVIAC title. Shepherd advanced to the NCAA Division II playoffs, where they beat in the first round, in the second round, and in the quarterfinals before losing in the semifinals at . The Rams played their home games at Ram Stadium in Shepherdstown, West Virginia.
The 2010 regular season for the Rams consisted of eight games against WVIAC conference opponents and two non-conference games against and . The Rams went 9–1 in the regular season and advanced to the 2010 NCAA Division II football playoffs.
The Rams won their first playoff game, at home against .[2] The team then went on to win two straight games on the road, against and, before losing in the semifinal round to .[2] [3] [4]