The 2010 Seguros Bolívar Open Bucaramanga was a professional tennis tournament played on outdoor red clay courts. It was part of the 2010 ATP Challenger Tour. It took place in Bucaramanga, Colombia between 25 and 31 January 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Eduardo Schwank | 95 | 1 | |
| Nicolás Massú | 97 | 2 | ||
 Spain | Santiago Ventura | 106 | 3 | |
 Colombia | Santiago Giraldo | 114 | 4 | |
| Spain | Pere Riba | 120 | 5 | |
 Romania | Victor Crivoi | 121 | 6 | |
 Brazil | Thiago Alves | 141 | 7 | |
| Brazil | Ricardo Mello | 142 | 8 |
The following players received wildcards into the singles main draw:
Ricardo Corrente Alejandro González Sebastián Serrano Eduardo StruvayThe following players received entry from the qualifying draw:
See main article: 2010 Seguros Bolívar Open Bucaramanga – Singles. Eduardo Schwank def. Juan Pablo Brzezicki, 6 - 4, 6 - 2
See main article: 2010 Seguros Bolívar Open Bucaramanga – Doubles. Pere Riba / Santiago Ventura def. Marcelo Demoliner / Rodrigo Guidolin, 6–2, 6–2