| Champ: |  Kei Nishikori |
| Runner: |  Brian Dabul |
| Score: | 2–6, 6–3, 6–4 |
| Type: | singles doubles |
See main article: 2010 Sarasota Open. James Ward was the defending champion, but he lost against Víctor Estrella in the first round.
Kei Nishikori, who played in this tournament as a 'special exempt', won in the final 2–6, 6–3, 6–4, against Brian Dabul.