| Date: | August 2 – August 8 |
| Edition: | 22nd |
| Location: | City of San Marino, San Marino |
| Champs: | Robin Haase |
| Champd: |  Daniele Bracciali / Lovro Zovko |
The 2010 San Marino CEPU Open was a professional tennis tournament played on outdoor red clay courts. It was the twenty second edition of the tournament which is part of the Tretorn SERIE+ of the 2010 ATP Challenger Tour. It took place in City of San Marino, San Marino between 2 and 8 August 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
| Italy | Potito Starace | 64 | 1 | |
 Belgium | Olivier Rochus | 66 | 2 | |
 Spain | Pere Riba | 73 | 3 | |
| Frederico Gil | 83 | 4 | ||
 Argentina | Carlos Berlocq | 101 | 5 | |
| Italy | Simone Bolelli | 109 | 6 | |
| Italy | Filippo Volandri | 110 | 7 | |
 France | Édouard Roger-Vasselin | 115 | 8 |
The following players received wildcards into the singles main draw:
Daniele Bracciali Flavio Cipolla Matteo Trevisan
Diego ZonziniThe following players received a Special Exempt into the main draw:
The following players received entry from the qualifying draw:
See main article: 2010 San Marino CEPU Open – Singles. Robin Haase def. Filippo Volandri, 6–2, 7–6(8)
See main article: 2010 San Marino CEPU Open – Doubles. Daniele Bracciali / Lovro Zovko def. Yves Allegro / 
James Cerretani, 3–6, 6–2, [10–5]
