| Year: | 2010 |
| Team: | Saint Francis Red Flash |
| Sport: | football |
| Conference: | Northeast Conference |
| Short Conf: | NEC |
| Record: | 1–10 |
| Conf Record: | 1–7 |
| Head Coach: | Chris Villarrial |
| Hc Year: | 1st |
| Off Coach: | Ralph DelSardo |
| Oc Year: | 1st |
| Def Coach: | Ralph Clark |
| Dc Year: | 1st |
| Stadium: | DeGol Field |
The 2010 Saint Francis Red Flash football team represented Saint Francis University as a member of the Northeast Conference (NEC) during the 2010 NCAA Division I FCS football season. The Red Flash were led by Chris Villarrial in his first year as the program’s 27th head coach and played their home games at DeGol Field. They finished the season 1–10 overall and 1–7 in NEC play to place last.