See main article: 2010 SA Tennis Open.
James Cerretani and Dick Norman were the defending doubles champions at the SA Tennis Open tournament, but Norman chose to not participate this year. Cerretani partnered up with Prakash Amritraj, but they lost in the first round 4–6, 6–7(6–8), against Eric Butorac and Rajeev Ram.
Rohan Bopanna and Aisam-ul-Haq Qureshi won in the final 6–2, 3–6, [10–5], against Karol Beck and Harel Levy. This was Qureshi's first ATP tour title.