The 2010 SA Tennis Open was a tennis tournament played on hard courts indoors. It was the 2nd edition of the SA Tennis Open and was part of the ATP World Tour 250 series of the 2010 ATP World Tour. It took place in Johannesburg, South Africa from 1 February through 7 February 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Gaël Monfils | 12 | 1 | |
| David Ferrer | 18 | 2 | ||
 Spain | Feliciano López | 46 | 3 | |
| Marco Chiudinelli | 58 | 4 | ||
| Rajeev Ram | 84 | 5 | ||
 Belgium | Xavier Malisse | 93 | 6 | |
| Lu Yen-hsun | 101 | 7 | ||
| France | Stéphane Robert | 104 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2010 SA Tennis Open – Singles. Feliciano López defeated Stéphane Robert, 7–5, 6–1
See main article: 2010 SA Tennis Open – Doubles. 
Rohan Bopanna / 
Aisam-ul-Haq Qureshi defeated 
Karol Beck / 
Harel Levy 6–2, 3–6, [10–5]
