| Season: | 2010 |
| Winners: | Étoile 1st S.League title |
| Continentalcup1 Qualifiers: | Tampines Rovers (S.League runners-up) |
| League Topscorer: | Frédéric Mendy (21) |
| Biggest Home Win: | Tampines Rovers 5–0 Woodlands Wellington (21 June 2010) Gombak United 5–0 Woodlands Wellington (1 July 2010) |
| Biggest Away Win: | Woodlands Wellington 0–4 Singapore Armed Forces (7 July 2010) |
| Matches: | 198 |
| Total Goals: | 464 |
| Nextseason: | 2011 |
The 2010 S.League (officially known as the Great-Eastern-Yeo's S-League for sponsorship reasons) was the 15th season since the establishment of the S-League. The season began on 1 February 2010, and ended on 12 November 2010.
Winners Etoile FC were ineligible to represent Singapore in AFC competitions as they were a foreign team. Tampines Rovers qualified as the runner-up for the 2011 AFC Cup.
Changes to the league include:
Each club is allowed to have up to a maximum of 4 foreign players.
| Club | Player 1 | Player 2 | Player 3 | Player 4 | Prime League | Former Player | |
|---|---|---|---|---|---|---|---|
| Balestier Khalsa |  Paul Cunningham | Daniel Hammond |  Rivaldo Costa | Vitor Borges |  Li Huai Min | None | |
| Geylang United |  Kim Jae-hong |  Vasile Ghindaru |  Rastislav Belicak | Peter Tomko | None | Miroslav Latiak | |
| Park Kang-jin | Jang Jo-yoon |  Goran Subara |  Obadin Aikhena | None | |||
| Choi Chul-woo | Chun Jae-woon | Ahn Hyo-yeon |  Valery Hiek | ||||
| Park Tae-won |  Ivan Lovric | Ivan Jerkovic |  Federico Martinez | ||||
| Sengkang Punggol | |||||||
 Seiji Kaneko | Akihiro Nakamura | Park Yo-seb |  Benoit Croissant | None | None | ||
| Kazuki Yoshino |  Abdelhadi Laakkad | Rachid Lajane |  Luis Eduardo Hicks |  Camilo Buitrago | None | ||
| Kim Seong-kyu | Seo Su-jong |  Luka Savic | None | None | None |
Fixtures and Results of the S. League 2010 season.
Note: The results are broken down into weeks rather than rounds, as some teams may play 2 or more games a week due to the nature of the league system (games are played every day). Hence, sometimes, teams may not play in the league some weeks due to other competition commitments or re-arranged games.
The opening week of the season runs from Monday 1 February to Friday 5 February. Official Site Weekly Review
----
----
The 2nd week of the season runs from Monday 8 February to Friday 12 February. Official Site Weekly Review
----
----
The 3rd week of the season runs from Tuesday 16 February to Friday 19 February. Official Site Weekly Review
----
----
The 4th week of the season runs from Monday 8 March to Friday 12 March. Official Site Weekly Review
----
The 5th week of the season runs from Sunday 14 March to Friday 19 March. Official Site Weekly Review
--------
The 6th week of the season runs from Monday 22 March to Saturday 27 March. Official Site Weekly Review
----
----
The 7th week of the season runs from Monday 29 March to Friday 2 April. Official Site Weekly Review
----
----
The 8th week of the season runs from Monday 5 April to Saturday 10 April. Official Site Weekly Review
--------
The 9th week of the season runs from Monday 12 April to Friday 16 April. Official Site Weekly Review
--------
The 10th week of the season runs from Monday 19 April to Saturday 24 April. Official Site Weekly Review
--------
The 11th week of the season runs from Monday 26 April to Friday 30 April. Official Site Weekly Review
--------
The 12th week of the season runs from Monday 3 May to Saturday 8 May. Official Site Weekly Review
--------
The 13th week of the season runs from Monday 10 May to Saturday 15 May. Official Site Weekly Review
--------
The 14th week of the season runs from Monday 17 May to Saturday 22 May. Official Site Weekly Review--------
The 15th week of the season runs from Tuesday 1 June to Sunday 6 June. Official Site Weekly Review--------
The 16th week of the season runs from Monday 7 June to Friday 11 June. Official Site Weekly Review--------
The 17th week of the season runs from Sunday 13 June to Saturday 19 June. Official Site Weekly Review--------
The 18th week of the season runs from Monday 21 June to Saturday 26 June. Official Site Weekly Review--------
The 19th week of the season runs from Monday 28 June to Sunday 4 July. Official Site Weekly Review--------
The 20th week of the season runs from Monday 5 July to Friday 9 July. Official Site Weekly Review--------
The 21st week of the season runs from Monday 12 July to Sunday 18 July. Official Site Weekly Review--------
The 22nd week of the season runs from Monday 19 July to Sunday 25 July.Official Site Weekly Review--------
The 23rd week of the season runs from Monday 26 July to Sunday 1 August. Official Site Weekly Review--------
The 24th week of the season runs from Monday 2 August to Sunday 8 August. Official Site Review----
The 25th week of the season runs from Monday 30 August to Sunday 5 September. Official Site Weekly Review----------------------------------------
The 26th week of the season runs from Monday 6 September to Wednesday 8 September. Official Site Weekly Review
----------------
The 27th week of the season runs from Monday 13 September to Friday 17 September. Official Site Weekly Review
----------------
The 28th week of the season runs from Tuesday 21 September to Friday 24 September. Official Site Weekly Review
----------------
The 29th week of the season runs from Monday 27 September to Wednesday 29 September. Official Site Weekly Review
--------
The 30th week of the season runs from Monday 4 October to Thursday 7 October. Official Site Weekly Review
--------------------
The 31st week of the season runs from Monday 11 October to Thursday 14 October. Official Site Weekly Review
--------------------
The 32nd week of the season runs from Monday 18 October to Sunday 24 October. Official Site Weekly Review
--------------------------------
The 33rd week of the season will be played on Tuesday 26 October.
--------
The 34th week of the season will be played on Wednesday 3 November.
----
The 35th week of the season will be played from Wednesday 10 November to Friday 12 November.
--------------------
| Team | Stadium | Capacity | Notes | |
|---|---|---|---|---|
| Albirex Niigata (S) | Jurong East Stadium | 2,700 | ||
| Balestier Khalsa | Toa Payoh Stadium | 3,900 | ||
 Beijing Guoan Talent | Yishun Stadium | 3,400 | ||
| Étoile | Queenstown Stadium | 3,800 | ||
| Geylang United | Bedok Stadium | 3,900 | ||
| Gombak United | Jurong West Stadium | 3,200 | ||
| Home United | Clementi Stadium | 4,000 | Moved from Bishan Stadium which is undergoing upgrading | |
| Singapore Armed Forces | Choa Chu Kang Stadium | 4,600 | ||
| Sengkang Punggol | Hougang Stadium | 2,500 | ||
| Tampines Rovers | Tampines Stadium | 3,600 | ||
| Woodlands Wellington | Woodlands Stadium | 4,300 | ||
| Jalan Besar Stadium | 6,000 |