The 2010 Ritro Slovak Open was a professional tennis tournament played on indoor hard courts. It was the eleventh edition of the tournament which was part of the Tretorn SERIE+ series of the 2010 ATP Challenger Tour and the 2010 ITF Women's Circuit. It took place in Bratislava, Slovakia between 15 and 21 November 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Russian Federation | Teymuraz Gabashvili | 81 | 1 | |
 Ukraine | Illya Marchenko | 96 | 2 | |
 France | Adrian Mannarino | 97 | 3 | |
 Poland | Michał Przysiężny | 100 | 4 | |
 Slovakia | Lukáš Lacko | 102 | 5 | |
| Dustin Brown | 105 | 6 | ||
 Slovenia | Blaž Kavčič | 109 | 7 | |
| Russian Federation | Igor Kunitsyn | 111 | 8 |
The following players received wildcards into the singles main draw:
The following player received a Special Exempt into the singles main draw:
The following players received entry from the qualifying draw:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Austria | Patricia Mayr | 100 | 1 | |
| Russian Federation | Evgeniya Rodina | 103 | 2 | |
 Czech Republic | Andrea Hlaváčková | 106 | 3 | |
| Ukraine | Kateryna Bondarenko | 113 | 4 | |
| Slovakia | Zuzana Kučová | 122 | 5 | |
| France | Irena Pavlovic | 200 | 6 | |
| Czech Republic | Karolína Plíšková | 203 | 7 | |
| Mona Barthel | 208 | 8 |
The following players received wildcards into the singles main draw:
Anna Karolína Schmiedlová Chantal Škamlová Jana Čepelová Zuzana LuknárováThe following players received entry from the qualifying draw:
Réka-Luca Jani Klaudia Boczová Michaela Hončová Lenka Tvarošková Lucia ButkovskáSee main article: 2010 Ritro Slovak Open – Men's singles. Martin Kližan def. Stefan Koubek, 7–6(4), 6–2
See main article: 2010 Ritro Slovak Open – Women's singles. Kateryna Bondarenko def. Evgeniya Rodina, 7–6(3), 6–2
See main article: 2010 Ritro Slovak Open – Men's doubles. 
Colin Fleming / Jamie Murray def. 
Travis Parrott / Filip Polášek, 6–2, 3–6, [10–6]
See main article: 2010 Ritro Slovak Open – Women's doubles. 
Emma Laine / Irena Pavlovic def. Claire Feuerstein / Valeria Savinykh, 6–4, 6–4