| Champ: |  Sam Querrey |
| Runner: | John Isner |
| Score: | 6–7(3–7), 7–6(7–5), 6–3 |
| Draw: | 32 |
| Seeds: | 8 |
See main article: 2010 Regions Morgan Keegan Championships and the Cellular South Cup. Andy Roddick was the defending champion, but lost in the quarterfinals to Sam Querrey.
Sam Querrey won in the final 6–7(3–7), 7–6(7–5), 6–3, against John Isner.