See main article: 2010 Prime Cup Aberto de São Paulo.
Carlos Berlocq and Leonardo Mayer were the defending champions, but chose not to participate that year.
Brian Dabul and Sebastián Prieto won in the final 6-3, 6-3 against Tomasz Bednarek and Mateusz Kowalczyk.
Sanchai Ratiwatana / Sonchat Ratiwatana (semifinals)
Brian Dabul / Sebastián Prieto (champions)
Jonathan Marray / Jamie Murray (semifinals)
David Martin / Frank Moser (first round)