| Date: | 1–7 November |
| Edition: | 4th |
| Surface: | Hard |
| Location: | Astana, Kazakhstan |
| Champs: | Ivan Dodig |
| Champd: |  Colin Fleming / Ross Hutchins |
The 2010 President's Cup was a professional tennis tournament played on outdoor hard courts. It was the fourth edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Astana, Kazakhstan between 1 and 7 November 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
 Kazakhstan | Mikhail Kukushkin | 88 | 1 | |
| Björn Phau | 89 | 2 | ||
| Rainer Schüttler | 103 | 3 | ||
 Russian Federation | Igor Kunitsyn | 106 | 4 | |
| Ivan Dodig | 118 | 5 | ||
 Austria | Martin Fischer | 122 | 6 | |
| Russian Federation | Konstantin Kravchuk | 133 | 7 | |
| Russian Federation | Alexander Kudryavtsev | 174 | 8 |
The following players received wildcards into the singles main draw:
Danjil Braun Evgeny Donskoy
Danai Udomchoke Serizhan YessenbekovThe following players received entry from the qualifying draw:
Mikhail Ledovskikh
Petru-Alexandru Luncanu Denis Matsukevich Vitali ReshetnikovSee main article: 2010 President's Cup – Singles. Ivan Dodig def. Igor Kunitsyn, 6–4, 6–3
See main article: 2010 President's Cup – Doubles. Colin Fleming / Ross Hutchins def. Mikhail Elgin / Alexander Kudryavtsev, 6–3, 7–6(10)