| Date: | July 19 – July 24 |
| Edition: | 5th |
| Location: | Penza, Russia |
| Champs: |  Mikhail Kukushkin |
| Champd: |  Mikhail Elgin /  Nikolaus Moser |
The 2010 Penza Cup was a professional tennis tournament played on Hard court. This was the fifth edition of the tournament which is part of the 2010 ATP Challenger Tour. It took place in Penza, Russia between 19 July and 24 July 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
| Kazakhstan | Mikhail Kukushkin | 96 | 1 | |
| Conor Niland | 161 | 2 | ||
 Ukraine | Ivan Sergeyev | 173 | 3 | |
| Russian Federation | Konstantin Kravchuk | 184 | 4 | |
 Belarus | Uladzimir Ignatik | 190 | 5 | |
| Russian Federation | Alexander Kudryavtsev | 206 | 6 | |
| Russian Federation | Evgeny Kirillov | 211 | 7 | |
 Spain | Iñigo Cervantes-Huegun | 217 | 8 |
The following players received wildcards into the singles main draw:
Victor Baluda Igor Karpov Ilya Kovalev Anton ManeginThe following players received entry from the qualifying draw:
See main article: 2010 Penza Cup – Singles. Mikhail Kukushkin def. Konstantin Kravchuk, 6–3, 6–7(3), 6–3
See main article: 2010 Penza Cup – Doubles. Mikhail Elgin / Nikolaus Moser def. Aliaksandr Bury / Kiryl Harbatsiuk, 6–4, 6–4