| Year: | 2010 |
| Team: | Penn Quakers |
| Sport: | football |
| Conference: | Ivy League |
| Short Conf: | Ivy |
| Record: | 9–1 |
| Conf Record: | 7–0 |
| Head Coach: | Al Bagnoli |
| Hc Year: | 19th |
| Off Coach: | Jon McLaughlin |
| Oc Year: | 2nd |
| Def Coach: | Ray Priore |
| Dc Year: | 13th |
| Stadium: | Franklin Field |
| Champion: | Ivy League champion |
The 2010 Penn Quakers football team represented the University of Pennsylvania in the 2010 NCAA Division I FCS football season. The Quakers were led by 19th-year head coach Al Bagnoli and played their home games at Franklin Field in Philadelphia. They finished the season 9–1 overall and 7–0 in Ivy League play, winning the conference title.