| Date: | 13 – 19 September |
| Edition: | 18th |
| Location: | Szczecin, Poland |
| Champs: | Pablo Cuevas |
| Champd: |  Dustin Brown / Rogier Wassen |
The 2010 Pekao Szczecin Open was a professional tennis tournament played on outdoor red clay courts. It was the 18th edition of the tournament which is part of the 2010 ATP Challenger Tour. It took place in Szczecin, Poland between 13 and 19 September 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
 Poland | Łukasz Kubot | 62 | 1 | |
| Pablo Cuevas | 88 | 2 | ||
| Tobias Kamke | 89 | 3 | ||
 Russian Federation | ||||
| Julian Reister | 106 | 5 | ||
 Spain | Pablo Andújar | 107 | 6 | |
| Nicolás Massú | 116 | 7 | ||
| Russian Federation | Igor Andreev | 121 | 8 | |
| Jamaica | Dustin Brown | 122 | 9 |
The following players received wildcards into the singles main draw:
Marcin Gawron Rafał Gozdur
Miloslav Mečíř Jr. Maciej SmołaThe following players received a special entrant into the singles main draw:
The following players received entry from the qualifying draw:
Nicolas Devilder
Daniel Lustig Laurent Rochette (as a Lucky Loser)See main article: 2010 Pekao Szczecin Open – Singles. Pablo Cuevas def. Igor Andreev, 6–1, 6–1
See main article: 2010 Pekao Szczecin Open – Doubles. Dustin Brown / Rogier Wassen def. 
Rameez Junaid / Philipp Marx, 6–4, 7–5