The 2010 Open d'Orléans was a professional tennis tournament played on hard courts. It was the sixth edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Orléans, France between 18 and 24 October 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Michaël Llodra | 28 | 1 | |
 Belgium | Xavier Malisse | 51 | 2 | |
 Slovakia | Lukáš Lacko | 73 | 3 | |
| France | Stéphane Robert | 93 | 4 | |
| Björn Phau | 99 | 5 | ||
| France | Adrian Mannarino | 108 | 6 | |
 Jamaica | Dustin Brown | 109 | 7 | |
| Belgium | Steve Darcis | 110 | 8 |
The following players received wildcards into the singles main draw:
The following players received a special entrant into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2010 Open d'Orléans – Singles. Nicolas Mahut def. Grigor Dimitrov, 2–6, 7–6(6), 7–6(4)
See main article: 2010 Open d'Orléans – Doubles. Pierre-Hugues Herbert / Nicolas Renavand def. Sébastien Grosjean / Nicolas Mahut, 7–6(3), 1–6, [10–6]
