| Champ: |  Gaël Monfils |
| Runner: | Ivan Ljubičić |
| Score: | 6–2, 5–7, 6–1 |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
| After Year: | 2012 |
| Before Name: | Grand Prix de Tennis de Lyon |
See main article: 2010 Open Sud de France. Ivan Ljubičić was the defending champion but lost in the final against Gaël Monfils, 6–2, 5–7, 6–1.
The top four seeds received a bye into the second round.