| Score: | 6–2, 4–6, [10–7] |
| Draw: | 16 |
| Seeds: | 4 |
| Type: | singles doubles |
| After Year: | 2012 |
| Before Name: | Grand Prix de Tennis de Lyon |
See main article: 2010 Open Sud de France. Julien Benneteau and Nicolas Mahut were the defending champions, however Benneteau was injured (left wrist).
As a result, Mahut competed with Arnaud Clément. They were eliminated by Gaël Monfils and Josselin Ouanna in the first round.
Stephen Huss and Ross Hutchins won the tournament after defeating Marc López and Eduardo Schwank 6–2, 4–6, [10–7] in the final.