The 2010 Open Sud de France was a men's tennis tournament played on indoor hard courts. It was the 24th edition of the Open Sud de France, and was part of the World Tour 250 Series of the 2010 ATP World Tour. It was held at the Arena Montpellier in Montpellier, France, from 25 October through 31 October 2010. It was the first edition to be held under the new title and the first in Montpellier, after Lyon lost the tournament. The tournament marked the first time since 1993 that top level professional tennis was played in the city. Gaël Monfils won the singles title.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Nikolay Davydenko | 11 | 1 | ||
| Jo-Wilfried Tsonga | 13 | 2 | ||
| Gaël Monfils | 15 | 3 | ||
| Ivan Ljubičić | 17 | 4 | ||
| John Isner | 20 | 5 | ||
| Albert Montañés | 23 | 6 | ||
| Richard Gasquet | 28 | 7 | ||
| David Nalbandian | 31 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2010 Open Sud de France – Singles. 
Gaël Monfils defeated Ivan Ljubičić, 6–2, 5–7, 6–1
See main article: 2010 Open Sud de France – Doubles. 
Stephen Huss / 
Ross Hutchins defeated 
Marc López / 
Eduardo Schwank, 6–2, 4–6, [10–7]
