See main article: 2010 Open GDF Suez. Amélie Mauresmo was the defending champion, but she retired from the sport on 3 December 2009.
Elena Dementieva won the title, defeating Lucie Šafářová in the final 6–7(5–7), 6–1, 6–4. This was Dementieva's final WTA singles title, before her retirement at the end of 2010.
The top two seeds received a bye into the second round.