Three provincial by-elections were held in Nova Scotia to fill vacancies in the House of Assembly.
The district of Glace Bay was vacated by Liberal Party MNA Dave Wilson; Geoff MacLellan won the election to replace him on June 22, 2010.
|NDP|Myrtle Campbell|align="right"|2281|align="right"|31.52|align="right"| |PC|Michelle Wheelhouse|align="right"|759|align="right"|10.48|align="right"| |Independent|Edna Lee|align="right"|195|align="right"|2.69|align="right"|
The district of Yarmouth was vacated by Liberal Party MNA Richard Hurlburt; Zach Churchill won the election to replace him on June 22, 2010.
|Progressive Conservative|Charles Crosby|align="right"|2628|align="right"|33.41|align="right"|-27.93 |Independent|Belle Hatfield|align="right"|673|align="right"|8.56|align="right"|Ø |New Democratic Party|John Deveau|align="right"|513|align="right"|6.52|align="right"|-16.41|}
The district of Cumberland South was vacated by Progressive Conservative MNA Murray Scott; Jamie Baillie won the election to replace him on October 26, 2010.
|- |Progressive Conservative|Jamie Baillie|align="right"|3,262|align="right"|57.20%|align="right"| |New Democratic Party|Scott McKee|align="right"|276|align="right"|4.84%|align="right"||}