| Date: | June 28 - July 4 |
| Edition: | 19th |
| Surface: | Hard |
| Location: | Winnetka, United States |
| Champs: |  Brian Dabul |
| Champd: |  Ryler DeHeart /  Pierre-Ludovic Duclos |
The 2010 Nielsen Pro Tennis Championship was a professional tennis tournament played on outdoor hard courts. It was the 19th edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Winnetka, Illinois, between 28 June and 4 July 2010.
| Nationality | Player | Ranking* | Seeding | |
|---|---|---|---|---|
| Björn Phau | 100 | 1 | ||
| Michael Russell | 101 | 2 | ||
 India | Somdev Devvarman | 103 | 3 | |
| Argentina | Brian Dabul | 111 | 4 | |
| Donald Young | 113 | 5 | ||
 France | Édouard Roger-Vasselin | 116 | 6 | |
 Japan | Go Soeda | 124 | 7 | |
| Kevin Kim | 142 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry as alternative:
The following players received entry from the qualifying draw:
See main article: article and 2010 Nielsen Pro Tennis Championship – singles. Brian Dabul def. Tim Smyczek, 6–1, 1–6, 6–1
See main article: article and 2010 Nielsen Pro Tennis Championship – doubles. Ryler DeHeart / Pierre-Ludovic Duclos def. Rik de Voest / Somdev Devvarman, 7–6(4), 4–6, [10–8]
