The 2010 Natomas Men's Professional Tennis Tournament was a professional tennis tournament played on hard courts. It was the sixth edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Sacramento, United States between 4 and 11 October 2010.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Tobias Kamke | 88 | 1 | ||
| Donald Young | 106 | 2 | ||
| Julian Reister | 111 | 3 | ||
| Ryan Sweeting | 114 | 4 | ||
| Robert Kendrick | 151 | 5 | ||
 Australia | Carsten Ball | 153 | 6 | |
| Izak van der Merwe | 155 | 7 | ||
| Kevin Kim | 162 | 8 |
The following players received wildcards into the singles main draw:
Denis Kudla Michael McClune Dennis NovikovThe following players received entry from the qualifying draw:
Daniel Cox
Pierre-Ludovic DuclosSee main article: 2010 Natomas Men's Professional Tennis Tournament – Singles. John Millman def. Robert Kendrick, 6–3, 6–2
See main article: 2010 Natomas Men's Professional Tennis Tournament – Doubles. Rik de Voest / Izak van der Merwe def. Nicholas Monroe / Donald Young, 4–6, 6–4, [10–7]