The 2010 Madrid Masters (also known as the Mutua Madrileña Madrid Open for sponsorship reasons) was played on outdoor clay courts at the Park Manzanares in Madrid, Spain from May 7–16. It was the 9th edition of the event on the ATP and 2nd on the WTA. It was classified as an ATP World Tour Masters 1000 event on the 2010 ATP World Tour and a Premier Mandatory event on the 2010 WTA Tour.
| Player | Nationality | Ranking* | Seeding | |
|---|---|---|---|---|
| Roger Federer | 1 | 1 | ||
| Rafael Nadal | 3 | 2 | ||
| Andy Murray | 4 | 3 | ||
| Robin Söderling |  Sweden | 7 | 4 | |
| Fernando Verdasco | 9 | 6 | ||
| Jo-Wilfried Tsonga | 10 | 7 | ||
| Marin Čilić |  Croatia | 11 | 8 | |
| David Ferrer | 12 | 9 | ||
| Mikhail Youzhny | 15 | 10 | ||
 Czech Republic | ||||
| Gaël Monfils | 18 | 12 | ||
| John Isner | 21 | 13 | ||
| Sam Querrey | 22 | 14 | ||
| Stanislas Wawrinka | 23 | 15 | ||
| Thomaz Bellucci |  Brazil | 26 | 16 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
Juan Ignacio Chela
Oleksandr Dolgopolov Jr.
Daniel Gimeno Traver
Santiago Giraldo Daniel Muñoz de la Nava
Christophe RochusThe following players received lucky loser spots:
The following notable players withdrew from the event:
Novak Djokovic (allergies)
Andy Roddick (stomach virus) Juan Martín del Potro (right wrist)
Nikolay Davydenko (broken wrist) Tomáš Berdych (right hip injury) Juan Carlos Ferrero (knee injury) Tommy Haas (right hip surgery) Tommy Robredo (back injury)
Gilles Simon (right knee) Radek Štěpánek (fatigue) David Nalbandian (leg injury)| Player | Nationality | Ranking* | Seeding | |
|---|---|---|---|---|
| Serena Williams | 1 | 1 | ||
| Caroline Wozniacki |  Denmark | 2 | 2 | |
| Dinara Safina | 3 | 3 | ||
| Venus Williams | 4 | 4 | ||
| Svetlana Kuznetsova | 5 | 5 | ||
| Elena Dementieva | 6 | 6 | ||
| Jelena Janković | Serbia | 7 | 7 | |
| Samantha Stosur | 8 | 8 | ||
| Agnieszka Radwańska |  Poland | 9 | 9 | |
| Victoria Azarenka |  Belarus | 10 | 10 | |
| Maria Sharapova | 13 | 11 | ||
| Marion Bartoli | 14 | 12 | ||
| Li Na | 15 | 13 | ||
| Flavia Pennetta | 16 | 14 | ||
| Francesca Schiavone | 17 | 15 | ||
| Nadia Petrova | 18 | 16 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
Akgul Amanmuradova Iveta Benešová Alizé Cornet Kirsten Flipkens Beatriz García Vidagany Petra Kvitová Klára ZakopalováThe following player received the lucky loser spot:
The following notable players withdrew from this event:
Kim Clijsters (left foot) Yanina Wickmayer (elbow injury) Kateryna Bondarenko (left knee injury)See main article: 2010 Mutua Madrileña Madrid Open – Men's singles. Rafael Nadal defeated Roger Federer 6–4, 7–6(7–5)
See main article: 2010 Mutua Madrileña Madrid Open – Women's singles. Aravane Rezaï defeated Venus Williams 6–2, 7–5
See main article: 2010 Mutua Madrileña Madrid Open – Men's doubles. Bob Bryan / Mike Bryan defeated 
Daniel Nestor / Nenad Zimonjić 6–3, 6–4
See main article: 2010 Mutua Madrileña Madrid Open – Women's doubles. Serena Williams / Venus Williams defeated Gisela Dulko / 
Flavia Pennetta 6–2, 7–5
