The 2010 Monterrey Open was a tennis tournament played on outdoor hard courts. It was the second edition of the Monterrey Open and was categorized as an International tournament on the 2009 WTA Tour. It took place at the Sierra Madre Tennis Club in Monterrey, Mexico, from March 1 through March 7, 2010.
The tournament was headlined by former world no. 1 Jelena Janković, top-ranked Slovak players, Daniela Hantuchová and Dominika Cibulková, Ágnes Szávay, and Anastasia Pavlyuchenkova. Also in the field were Anabel Medina Garrigues, Aleksandra Wozniak, and 2010 Open GDF Suez finalist Lucie Šafářová.
| Athlete | Nationality | Ranking* | Seeding | |
|---|---|---|---|---|
| Jelena Janković |  Serbia | 9 | 1 | |
| Daniela Hantuchová |  Slovakia | 24 | 2 | |
| Anastasia Pavlyuchenkova |  Russia | 27 | 3 | |
| Dominika Cibulková | Slovakia | 28 | 4 | |
| Ágnes Szávay |  Hungary | 31 | 5 | |
| Anabel Medina Garrigues |  Spain | 34 | 6 | |
| Aleksandra Wozniak |  Canada | 35 | 7 | |
| Lucie Šafářová |  Czech Republic | 38 | 8 |
The following players received wildcards into the main draw:
The following players received entry via qualifying:
See main article: 2010 Monterrey Open – Singles. Anastasia Pavlyuchenkova defeated Daniela Hantuchová, 1–6, 6–1, 6–0
See main article: 2010 Monterrey Open – Doubles. Iveta Benešová / Barbora Záhlavová-Strýcová defeated Anna-Lena Grönefeld / 
Vania King, 3–6, 6–4, [10–8]
