See main article: 2010 Medibank International Sydney.
Hsieh Su-wei and Peng Shuai were the defending champions, but chose not to compete.
Cara Black and Liezel Huber won in the final, 6 - 1, 3 - 6, 10 - 3, against Tathiana Garbin and Nadia Petrova.
Liezel Huber (champions) Lisa Raymond / 
Rennae Stubbs (first round)
Alisa Kleybanova / 
Francesca Schiavone (second round) Vania King (semifinals)