| Year: | 2010 |
| Team: | McNeese State Cowboys |
| Sport: | football |
| Conference: | Southland Conference |
| Short Conf: | Southland |
| Record: | 6–5 |
| Conf Record: | 5–2 |
| Head Coach: | Matt Viator |
| Hc Year: | 5th |
| Cooff Coach1: | Broderick Fobbs |
| Cooc1 Year: | 4th |
| Cooff Coach2: | Tim Leger |
| Cooc2 Year: | 4th |
| Stadium: | Cowboy Stadium |
The 2010 McNeese State Cowboys football team represented McNeese State University as a member of the Southland Conference during the 2010 NCAA Division I FCS football season. Led by fifth-year head coach Matt Viator, the Cowboys compiled an overall record of 6–5 with a mark of 5–2 in conference play, placing second in the Southland. McNeese State played home games at Cowboy Stadium in Lake Charles, Louisiana.